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KMID : 0191120150300030240
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Journal of Korean Medical Science
2015 Volume.30 No. 3 p.240 ~ p.244
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Seasonality of Gout in Korea: A Multicenter Study
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Choi Hyo-Jin
Lee Chan-Hee
Lee Joo-Hyun
Yoon Bo-Young
Kim Hyoun-Ah
Suh Chang-Hee
Choi Sang-Tae
Song Jung-Soo
Joo Ho-Yeon
Choi Sung-Jae
Lee Ji-Soo
Shin Ki-Chul
Jun Hey-Jung
Baek Han-Joo
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Abstract
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The object of this study was to evaluate the seasonality of gout in Korea. We retrospectively examined data from 330 patients seen at nine rheumatology clinics, treated with urate lowering therapy (ULT) more than one year after stopping prophylactic medication. Demographic data, clinical and laboratory features, and seasonality of gout onset and flares were collected. Season was classified in three-month intervals. The mean age was 52.2 yr and mean disease duration was 26.8 months. The male to female count was 318:12. The onset of acute gouty attacks was obtained in 256 patients. Gout developed most commonly in summer season (36.7%) (P<0.001) and in June (15.6%, P=0.002). During ULT, there were 147 (male 97.3%) gout flares. Although there was no statistically significant difference, gout flares were more common in summer (30.6%). Aggravating factors were identified in 57 flares: alcohol (72.0%) was most common. In the patients who attained target serum uric acid (<6 mg/dL) at the end of prophylaxis, gout flares were high in fall (35.8%) and September (17.0%). In Korea, the summer is most common season of gout onset and there is a tendency for gout flares to increase during ULT in summer/fall season.
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KEYWORD
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Gout Onset, Flares, Seasonality, Summer, Korea
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